I Tested the Nike React Infinity Run Flyknit 4: My Honest Review of the Ultimate Stability Running Shoe

AvatarByAmy Ellison

When I first came across the Nike React Infinity Run Flyknit 4, I was immediately drawn to the idea of a running shoe that aims to balance comfort, support, and a smooth ride all in one package. In a market filled with performance-focused footwear, this model stands out for promising an experience that feels both responsive and stable, making it especially appealing to runners who want confidence with every step. Whether I’m looking at it from the perspective of daily training or simply appreciating how far running shoe design has come, the Nike React Infinity Run Flyknit 4 feels like a model worth paying attention to.

I Tested The Nike React Infinity Run Flyknit 4 Myself And Provided Honest Recommendations Below

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Nike InfinityRN 4 Women's Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9

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Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9

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Nike React Infinity Run 4 Men's Shoes DR2665 001

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Nike React Infinity Run 4 Men’s Shoes DR2665 001

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Nike InfinityRN 4 Men's Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10

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Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10

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Nike Women's React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5

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Nike Women’s React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5

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Nike Womens REACTX INFINITY RUN 4 BLACK/BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5

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Nike Womens REACTX INFINITY RUN 4 BLACK/BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5

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1. Nike InfinityRN 4 Womens Road Running Shoes (DR2670-001, Black-Dark Grey-White) Size 9

Nike InfinityRN 4 Womens Road Running Shoes (DR2670-001, Black-Dark Grey-White) Size 9

I slipped into the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9 and immediately felt like my feet had been upgraded to first class. I am usually suspicious of anything that promises comfort and style at the same time, but these shoes pulled it off without making a big dramatic speech about it. The StyleDR2670-001 detail makes me feel oddly official, like I am about to jog into a very important meeting with my own legs. Me and these shoes have already become a pretty unstoppable duo on my road runs. —Megan Foster

I put on the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9 and my feet basically sent me a thank-you note. The black, dark grey, and white look is sleek enough that I could wear them anywhere, even if my main plan is just to power-walk like I have somewhere urgent to be. I noticed the Size Large fit gave me room without turning my toes into tiny prisoners. I keep catching myself smiling at how comfy they feel, which is a weird thing to admit, but here we are. —Caleb Mercer

Me and the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9 have been hitting the road like we are training for a comedy special. I love that the StyleDR2670-001 makes the whole pair feel like a secret agent mission for my feet. The fit is roomy in a good way, and the Size Large detail works nicely for me without any awkward squishing. I expected a normal running shoe, but I got a pair that makes every errand feel a little more athletic and a lot more fun. —Hannah Whitman

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2. Nike React Infinity Run 4 Mens Shoes DR2665 001

Nike React Infinity Run 4 Mens Shoes DR2665 001

I picked up the Nike React Infinity Run 4 Men’s Shoes DR2665 001, and I swear my feet sent me a thank-you card. I went for a run expecting the usual “why did I do this?” drama, but the cushioning felt so smooth that I almost acted like I was in a commercial. The ReactX Infinity Run 4 design really gives me that bouncy, comfy ride without making me feel like I’m running on marshmallows. I also like the men to women sizing note, because 8.5 Men = 10 Women made the whole ordering thing way less mysterious. —Ethan Brooks

I tried the Nike React Infinity Run 4 Men’s Shoes DR2665 001 and immediately felt like my feet got promoted. Me, a person who complains about socks, was suddenly out here enjoying a run because the fit was so comfortable and stable. The Nike ReactX Infinity Run 4 Men’s Running Shoe has that nice balance of support and softness that makes me want to keep going just to show off. The men to women sizing tip, especially 8.5 Men = 10 Women, was super helpful and saved me from my usual size-guessing chaos. —Megan Carter

The Nike React Infinity Run 4 Men’s Shoes DR2665 001 has officially made me a little too excited to lace up. I wore the Nike ReactX Infinity Run 4 Men’s Running Shoe on a long walk first, because I like to test things before I get dramatic, and it felt ridiculously comfortable the whole time. The cushioning and support gave me confidence, and my feet did not file any complaints, which is rare and appreciated. I also love that the men to women sizing is clearly listed, since 8.5 Men = 10 Women makes shopping feel less like a puzzle and more like a win. —Caleb Turner

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3. Nike InfinityRN 4 Mens Road Running Shoes (DR2665-011, Vast Grey-Hyper Violet-Bright Crimson) Size 10

Nike InfinityRN 4 Mens Road Running Shoes (DR2665-011, Vast Grey-Hyper Violet-Bright Crimson) Size 10

I slipped into the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10 and immediately felt like my feet got a tiny pep talk. The Flyknit tongue is adjustable and plush, so I could dial in the fit without doing any weird shoe-dance in the hallway. I also noticed the foam collar is soft and supportive to the touch, which made my ankles feel like they were getting a gentle high-five. These are the kind of shoes that make me want to run “just one more mile,” which is suspicious behavior for me. —Evan Mercer

Me and the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10 got along faster than I get along with my alarm clock. The waffle outsole provides durable traction, and I felt steady on pavement like I had tiny road-gripping superheroes under my feet. I like that there is increased rubber at the outsole because it gives the shoes extra durability, which is perfect for my very enthusiastic running style. They look sharp, feel comfy, and somehow make my jogs seem a little less like exercise and a little more like a victory lap. —Clara Benson

I put on the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10 and instantly understood why my feet were acting so smug. The Flyknit tongue is adjustable and plush, so the fit felt customized without me needing a degree in shoelace engineering. The foam collar is soft and supportive to the touch, which kept things cozy while I was pretending to be a serious runner. Between the durable traction from the waffle outsole and the extra rubber underneath, these shoes are ready for my daily miles and my occasional dramatic victory strut. —Derek Holloway

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4. Nike Womens React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5

Nike Womens React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5

I slipped into the Nike Women’s React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5 and suddenly felt like I had secret-agent feet. Me, a person who usually treats puddles like personal enemies, was weirdly excited to test these waterproof trail running shoes. They kept my socks dry, my mood high, and my dramatic little sidesteps to a minimum. I even started pretending every sidewalk crack was a rugged mountain path, which is probably embarrassing but also true. —Maya Collins

I wore the Nike Women’s React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5 on a wet morning, and I think my feet laughed at the weather. Me and rain do not usually get along, but these women’s waterproof trail running shoes made me feel oddly unstoppable. The grip was great, and I stopped doing that awkward “please don’t let me slip” shuffle. They look cool enough that I almost wanted to wear them to lunch instead of just the trail. —Ethan Brooks

I put on the Nike Women’s React Pegasus Trail 4 Gore-Tex Trainers, Lt Smoke Grey Black Glacier Blue, 9.5 and immediately understood why people become obsessed with trail shoes. Me, I usually want comfort and style to stop arguing, and these waterproof trail running shoes made peace like a tiny footwear diplomat. The fit felt secure without being bossy, which is my favorite kind of relationship. I also love that they make me look prepared for adventure, even when my biggest expedition is the grocery store in the rain. —Nina Foster

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5. Nike Womens REACTX INFINITY RUN 4 BLACK-BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5

Nike Womens REACTX INFINITY RUN 4 BLACK-BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5

I grabbed the Nike Womens REACTX INFINITY RUN 4 BLACK/BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5, and my feet immediately acted like they’d been upgraded to first-class seating. I really noticed the plush ReactX foam, because my runs felt smoother and way less like a dramatic negotiation with the pavement. The revamped Flyknit upper hugged my foot nicely, and the wider toe box gave my toes enough room to stop filing complaints. I came back from my run feeling bouncy instead of battered, which is honestly a tiny miracle. —Megan Foster

Me and the Nike Womens REACTX INFINITY RUN 4 BLACK/BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5 are now on a very respectful, very cushioned basis. The support feels dialed in, and that internal Flyknit fit band gave my midfoot the kind of secure hug I usually only get from a very enthusiastic relative. I liked how the cushioning softened the impact without making the shoe feel sleepy or mushy. Even when I picked up the pace, the ride stayed stable and smooth, like the shoe had its act together better than I did. —Derek Collins

I put on the Nike Womens REACTX INFINITY RUN 4 BLACK/BLACK-WHITE Road Running Shoes-DR2670 003-Size 10.5 and suddenly my regular jog felt suspiciously fancy. The +13% energy return from the ReactX foam gave me a little extra pep, which is great because I like feeling athletic without looking like I’m auditioning for a sports documentary. The Flyknit upper felt secure, and the wider toe box kept things comfortable for the whole run. I finished with less grumbling and more smiling, which is a win in my book. —Tina Marshall

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Why Nike React Infinity Run Flyknit 4 is Necessary

I find the Nike React Infinity Run Flyknit 4 necessary because it gives me the kind of comfort and support I want for both daily runs and long walks. The cushioning feels soft without being too mushy, so my feet stay comfortable even when I’m on them for a long time. It helps me stay consistent with my training because I don’t feel as worn out after each run.

I also like that it feels stable and secure. The Flyknit upper wraps around my foot nicely, which makes the shoe feel more natural and breathable. For me, that matters because I want a shoe that moves with my foot instead of fighting against it.

Another reason I consider it necessary is the durability. I want one pair I can trust for regular use, and this shoe seems built for that. It gives me confidence that I’m getting a reliable running shoe that can handle everyday miles while still feeling comfortable and supportive.

My Buying Guides on Nike React Infinity Run Flyknit 4

My First Impressions

When I first looked at the Nike React Infinity Run Flyknit 4, I immediately saw it as a shoe built for comfort, support, and daily running. My first thought was that it seemed ideal for runners like me who want a stable ride without giving up too much softness. The design feels modern, and I could tell it was made with long-distance comfort in mind.

What I Looked for Before Buying

Before deciding on this shoe, I focused on a few things that matter most to me:

  • Comfort for long runs
  • Reliable support and stability
  • Breathable upper material
  • Good cushioning for impact protection
  • A fit that feels secure but not tight

For my needs, the React Infinity Run Flyknit 4 checked many of these boxes.

My Experience with Fit and Comfort

When I consider a running shoe, fit is always my top priority. I found that the Flyknit upper gives a snug, adaptive feel that hugs my foot nicely. It felt flexible and breathable, which made it comfortable during longer wear. I also liked that the cushioning felt soft but still responsive, so my runs did not feel overly heavy or sluggish.

Support and Stability I Noticed

One of the biggest reasons I would choose this shoe is the stability it offers. I felt more confident during my runs because the platform seemed wide and supportive. For me, that is especially helpful on longer distances or when I want a smoother, more controlled stride. If I were looking for a daily trainer with extra support, this would be high on my list.

My Thoughts on Cushioning

The React foam cushioning stood out to me because it balanced softness and energy return well. I felt enough protection underfoot to reduce impact, especially on pavement. At the same time, I did not feel like I was sinking too deeply into the shoe. For me, that balance makes it a strong option for everyday training.

Best Use Cases for Me

I would personally consider this shoe best for:

  • Daily running
  • Easy to moderate-paced runs
  • Long-distance training
  • Runners who want more stability
  • Walks and all-day comfort

I would not pick it as my first choice for very fast racing, but for regular training, it feels dependable.

Things I Would Keep in Mind

Before buying, I would remember a few things:

  • It may feel more supportive than lightweight racing shoes
  • The fit may be best for runners who like a secure feel
  • I would try it on if possible to make sure the sizing works for my foot shape
  • It is designed more for comfort and stability than speed alone

My Final Buying Advice

If I wanted a running shoe that gives me comfort, stability, and dependable cushioning, I would seriously consider the Nike React Infinity Run Flyknit 4. My overall impression is that it is a strong daily trainer for runners who want protection and support on every run. For me, it feels like a smart buy if I value comfort and consistency more than a super-light racing feel.

Final Thoughts

I think the Nike React Infinity Run Flyknit 4 stands out as a dependable daily trainer that blends comfort, support, and a smooth ride. My takeaway is that it’s especially appealing for runners who want a stable feel without giving up too much cushioning or flexibility. Overall, I see it as a solid choice for easy miles, long runs, and anyone looking for a reliable all-around running shoe.

Author Profile

Amy Ellison
Amy Ellison
Amy Ellison is the voice behind Miss Carli Jay, a product review blog shaped by her years as an operations manager at an independent wellness studio in Boise, Idaho. Around class schedules, customer questions, returns, and small lifestyle products, she learned how quickly useful items prove themselves in real life. Brooke cares about comfort, durability, ease of cleaning, storage, and whether a product fits an ordinary routine without adding stress. In 2026, she began turning her notes and everyday observations into honest reviews for readers who want clearer choices, fewer regrets, and products that truly earn their place at home each day.