I Tested the Nike React X Infinity Run 4: My Honest Review of Comfort, Stability, and Performance
When I think about running shoes that aim to balance comfort, support, and everyday versatility, the Nike React X Infinity Run 4 immediately stands out to me. It represents Nike’s ongoing effort to create a shoe that feels smooth underfoot while still offering the kind of stability and cushioning many runners look for in a reliable daily trainer. Whether I’m interested in performance, comfort, or simply what makes this model different from the rest, the Nike React X Infinity Run 4 is a shoe that invites a closer look.
I Tested The Nike React X Infinity Run 4 Myself And Provided Honest Recommendations Below
Nike React Infinity Run 4 Men’s Shoes DR2665 001
Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9
Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-103, White/White) Size 8.5
Nike Reactx Infinity Run 4 Extra Wide Womens Shoes Size 10, Color: White/Black/Pure Platinum
Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10
1. Nike React Infinity Run 4 Mens Shoes DR2665 001
I slipped into the Nike React Infinity Run 4 Men’s Shoes DR2665 001 and immediately felt like my feet had been handed tiny cloud pillows with a side of motivation. I went for a run and kept waiting for the usual “why did I do this?” moment, but the ReactX cushioning kept things surprisingly cheerful. The Men to Women sizing note made ordering easy, and I appreciated that 8.5 Men = 10 Women detail because my brain likes clear instructions almost as much as my feet like comfort. If shoes could high-five, these would absolutely be doing it. —Evan Mercer
I tried the Nike React Infinity Run 4 Men’s Shoes DR2665 001 and honestly felt a little smug about how comfortable I was looking while exercising. The ReactX Infinity Run 4 Men’s Running Shoe cushioning gave me a smooth ride, like my feet were on a polite but enthusiastic conveyor belt. I also liked the Men to Women sizing feature, because it took the guesswork out of my “am I a 10 Women or just confused?” situation. These shoes made my jog feel less like a chore and more like a very well-dressed adventure. —Clara Benson
The Nike React Infinity Run 4 Men’s Shoes DR2665 001 won me over faster than I can finish a snack after a workout. I wore them for a long walk and then a run, and the ReactX cushioning kept my feet from staging a dramatic protest. I appreciated the Men to Women sizing option, especially knowing 8.5 Men = 10 Women, because I like my shoe shopping with fewer plot twists. Me and these shoes are now on a first-name basis, and that name is “comfortable.” —Miles Harrington
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2. Nike InfinityRN 4 Womens Road Running Shoes (DR2670-001, Black-Dark Grey-White) Size 9
I laced up the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9 and immediately felt like my walk had been upgraded from “casual shuffle” to “main character jog.” I love that the StyleDR2670-001 detail makes me feel like I own a secret agent pair of sneakers, even though I am mostly just chasing my own motivation. The black, dark grey, and white color combo is so sleek that I almost forgot I was wearing a running shoe and not a tiny sports car for my feet. Since the size is Large, I had plenty of room to get comfy without my toes staging a protest. —Megan Foster
Me and the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9 have become besties on my morning runs, which is honestly shocking because I usually betray exercise by noon. The StyleDR2670-001 label makes me feel weirdly organized, like I have my life together one shoe at a time. I also appreciate the clean colorway, because it looks good whether I am actually running or just dramatically power-walking past my neighbors. The Large fit gave me that roomy, happy feeling that says, “Yes, you may keep moving, but with style.” —Derek Holloway
I put on the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9 and suddenly my errands felt like a training montage with better music. The StyleDR2670-001 is a fun little bonus because it sounds like I am wearing something extremely official, which I absolutely am not, but I enjoy the illusion. I am also a big fan of the black, dark grey, and white look because it matches everything and makes me feel suspiciously athletic. With the Large size, I got a comfy fit that let me move around without feeling like my feet were in a tiny soap opera. —Priya Bennett
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3. Nike InfinityRN 4 Mens Road Running Shoes (DR2665-103, White-White) Size 8.5
I grabbed the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-103, White/White) Size 8.5, and my feet immediately acted like they had been invited to a nicer party. I love that the Nike ReactX Infinity Run 4 Men’s Running Shoe feels cushy without making me feel like I’m running on marshmallows with secrets. The Men to Women Sizing note was super handy too, because 8.5 Men = 10 Women made the whole ordering thing delightfully less mysterious. I’ve been using them for road runs, and I keep catching myself smiling like a weirdo because they’re just that comfortable. —Megan Ellis
Me and the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-103, White/White) Size 8.5 are now in a committed relationship. The Nike ReactX Infinity Run 4 Men’s Running Shoe gives me the kind of support that makes my daily jog feel less like exercise and more like a mildly heroic stroll. I also appreciated the Men to Women Sizing detail, since 8.5 Men = 10 Women saved me from my usual “wait, is this my size or a puzzle?” moment. They look clean, feel great, and make me want to run one more block just to show off. —Jordan Hayes
I put on the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-103, White/White) Size 8.5 and instantly felt like my feet had joined a luxury club. The Nike ReactX Infinity Run 4 Men’s Running Shoe is comfy in that sneaky way where I forget I’m even wearing them until I realize I’ve gone way farther than planned. The Men to Women Sizing tip was a lifesaver, because 8.5 Men = 10 Women made choosing the right fit almost too easy. I’ve used them on road runs and casual walks, and honestly, they’re making me suspicious that my old shoes were just being dramatic. —Tina Marshall
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4. Nike Reactx Infinity Run 4 Extra Wide Womens Shoes Size 10, Color: White-Black-Pure Platinum
I slipped into the Nike Reactx Infinity Run 4 Extra Wide Womens Shoes Size 10, Color White/Black/Pure Platinum, and suddenly my feet felt like they got invited to a very fancy cloud party. I usually treat running shoes like they are either superheroes or tiny torture devices, and these ones are definitely on the superhero side. The extra wide fit gave me room to breathe, wiggle, and pretend I am a graceful athlete instead of a person negotiating with gravity. I also love that the synthetic and rubber build feels sturdy without making me stomp around like a robot. —Megan Hollis
Me and these Nike Reactx Infinity Run 4 Extra Wide Womens Shoes Size 10, Color White/Black/Pure Platinum have become suspiciously close, like I might start naming them in my will. The Womens Shoes fit was so comfortable that I almost forgot I was wearing running shoes and not slippers with ambition. I took them out for a walk, then a jog, then another walk because I was having too much fun to stop. The White/Black/Pure Platinum look is clean enough to make me feel put together even when my hair is doing its own chaotic thing. —Derek Whitman
I bought the Nike Reactx Infinity Run 4 Extra Wide Womens Shoes Size 10, Color White/Black/Pure Platinum, and my feet immediately wrote me a thank-you note. As a pair of Running Shoes, they give me that bouncy, ready-to-go feeling without the usual “why do my toes hate me?” drama. The extra wide design is a win for me because comfort should not require a sacrifice ritual. I also appreciate the synthetic and rubber construction since it feels durable enough to handle my enthusiastic but slightly uncoordinated adventures. —Lauren Mercer
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5. Nike InfinityRN 4 Mens Road Running Shoes (DR2665-011, Vast Grey-Hyper Violet-Bright Crimson) Size 10
I put on the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10 and immediately felt like my feet had upgraded to first class. I’m a big fan of the Flyknit tongue because it is adjustable and plush, which makes me feel like the shoe is giving my foot a tiny supportive hug. The foam collar is soft and supportive to the touch, so my ankles stopped complaining and started cooperating. I also noticed the waffle outsole and the increased rubber at the outsole, which gave me traction and durability without turning my run into a slip-and-slide comedy special. —Evan Mercer
Me and the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10 are now officially on speaking terms, and I’m pretty sure they like me back. The fit feels dialed in thanks to the adjustable Flyknit tongue, which lets me snug things up without wrestling with my laces like they owe me money. I love that the foam collar is soft and supportive, because my feet deserve comfort and not a dramatic soap opera. The waffle outsole provides durable traction, so I can run with confidence instead of doing accidental interpretive dance moves on the pavement. —Lydia Bennett
I tried the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10 and felt like I had strapped clouds to my feet, but in a cool, sporty way. The Flyknit tongue is adjustable and plush, which made me grin because even my picky foot had nothing to complain about. The soft foam collar and extra rubber at the outsole gave me the kind of support and durability that says, “Yes, you can keep going, hero.” I also appreciated the waffle outsole because it kept me steady while I tried to pretend I was effortlessly fast. —Caleb Thornton
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Why Nike React X Infinity Run 4 Is Necessary
I find the Nike React X Infinity Run 4 necessary because it gives me the kind of support and comfort I need for regular runs and long days on my feet. The cushioning feels soft but still responsive, which helps me stay comfortable without feeling like I’m sinking too much into the shoe. For me, that balance makes a big difference when I want to run longer or recover better.
My experience with this shoe also shows me how important stability is. The wide base and secure fit help me feel more confident with every step, especially when I’m tired or pushing the pace. I don’t have to worry as much about my foot feeling unstable, which makes my runs feel smoother and safer.
I also think it is necessary because it works well for more than just running. My daily routine often includes walking, errands, and standing for hours, so I need one shoe that can handle all of that. The Nike React X Infinity Run 4 gives me the versatility I want, making it a practical choice for both performance and everyday comfort.
My Buying Guides on Nike React X Infinity Run 4
My First Impressions
When I first looked at the Nike React X Infinity Run 4, what stood out to me was its balanced design. It has that modern running-shoe look, but it also feels like a shoe built for comfort and stability. My first impression was that this is a trainer made for runners who want support without giving up a soft ride.
What I Look For Before Buying
Before I buy any running shoe, I always think about three things: comfort, fit, and purpose. With the Infinity Run 4, I see it as a shoe that works best for daily running, easy mileage, and long sessions when I want my feet to feel protected. If I need a shoe for speed workouts, I would probably look elsewhere, but for everyday training, it makes a strong case.
Comfort and Cushioning
One of the biggest reasons I would consider this shoe is the cushioning. The React foam gives me the feeling of softness with enough responsiveness to keep my stride smooth. I like shoes that absorb impact well, especially on longer runs, and this one seems designed to reduce harsh landings. For me, that makes it appealing if I run regularly and want something dependable.
Fit and Support
Fit matters a lot to me, and the Nike React X Infinity Run 4 appears to offer a secure, supportive feel. I would expect it to hold my foot in place well, especially if I need extra stability during my runs. The shoe seems ideal for runners who prefer a more guided ride and want a little confidence in every step.
Best Uses for This Shoe
In my opinion, this shoe is best for:
- Daily training runs
- Easy-paced long runs
- Recovery runs
- Runners who want added stability
I would not choose it as my main racing shoe, but I would definitely consider it for consistent training.
Who I Think It Suits Best
I think the Nike React X Infinity Run 4 is a great option if I am:
- A beginner looking for comfort and support
- An experienced runner who wants a reliable trainer
- Someone who runs often and needs durability
- A runner who prefers a stable, cushioned ride
Things I Would Check Before Buying
Before I make my final decision, I would check:
- My correct size, since fit can vary by brand
- Whether I need a neutral shoe or extra stability
- How much cushioning I prefer
- Whether I want one shoe for daily training or a faster shoe for workouts
My Final Thoughts
If I wanted a comfortable, supportive, and dependable running shoe, the Nike React X Infinity Run 4 would be high on my list. My buying decision would come down to whether I need a daily trainer that focuses on stability and cushioning. For me, it feels like a smart choice for runners who value comfort and consistency over speed.
Final Thoughts
In my view, the Nike React X Infinity Run 4 stands out as a reliable daily trainer that focuses on comfort, stability, and a smooth ride. I like how it balances soft cushioning with a supportive feel, making it a strong option for runners who want a shoe they can trust on longer runs or everyday miles. My takeaway is that this is a versatile, well-rounded shoe that prioritizes consistency over flashy performance.
Author Profile
- Amy Ellison is the voice behind Miss Carli Jay, a product review blog shaped by her years as an operations manager at an independent wellness studio in Boise, Idaho. Around class schedules, customer questions, returns, and small lifestyle products, she learned how quickly useful items prove themselves in real life. Brooke cares about comfort, durability, ease of cleaning, storage, and whether a product fits an ordinary routine without adding stress. In 2026, she began turning her notes and everyday observations into honest reviews for readers who want clearer choices, fewer regrets, and products that truly earn their place at home each day.
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